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Bibliography of 15 Key Published Clinical Studies Validating These Indications

Cardiovascular/Cardiothoracic
1. White PF, et al. Use of Continuous Local Anesthetic Infusion for Pain Management after Median Sternotomy.
Anesthesiology. Oct 2003; 99 (4): 918-23.
2. Dowling R, et al. Improved Pain Control after Cardiac Surgery: Results of a Randomized Double-Blinded Clinical Trial.
Journal of Thoracic and Cardiovascular Surgery. Nov 2003; 126 (5): 1271-8.
 
General
3. Cheong WK, et al. Randomized Clinical Trial of Local Bupivacaine Perfusion versus Parenteral Morphine Infusion for Pain
Relief after Laparotomy. British Journal of Surgery. 2001; 88: 357-9.
4. Rawal N, et al. Postoperative Patient-Controlled Local Anesthetic Administration at Home. Anesthesia & Analgesia. 1998;
86: 86-9.
5. Vintar N, et al. Incisional Self-Administration of Bupivacaine or Ropivacaine Provides Effective Analgesia after Inguinal
Hernia Repair. Canadian Journal of Anesthesiology. 2002; 49 (5): 481-6.
6. Morrison JE, Jacobs VR. Reduction or Elimination of Postoperative Pain Medication after Mastectomy through Use of a
Temporarily Placed Local Anaesthetic Pump vs. Control Group. Zentralblatt für Gynäkologie. 2003; 125: 17-22.
7. Gupta A, et al. Postoperative Pain Relief Using Intermittent Injections of 0.5% Ropivacaine through a Catheter after
Laparoscopic Cholecystectomy. Anesthesia & Analgesia. 2002; 95: 450-6.
8. Lau H, Patil NG, Lee F. Randomized Clinical Trial of Postoperative Subfascial Infusion with Bupivacaine Following
Ambulatory Open Mesh Repair of Inguinal Hernia Digestive Surgery. 2003; 20 (4): 285-9.
 
OB/GYN
9. Givens VA, Lipscomb GH and Meyer NL. A Randomized Trial of Postoperative Wound Irrigation with Local Anesthetic for
Pain after Cesarean Delivery. Am J Obstet Gynecol. 2002;186 (6):1188-91.
10. Fredman B, et al. The Analgesic Effi cacy of Patient-Controlled Ropivacaine Instillation after Cesarean Delivery. Anesthesia &
Analgesia. 2000; 91: 1436-40.
 
Orthopedic
11. Klein SM, et al. Interscalene Brachial Plexus Block with a Continuous Catheter Insertion System and a Disposable Infusion
Pump. Anesthesia & Analgesia. 2000: 91: 1473-8.
12. White PF, et al. Continuous Popliteal Sciatic Nerve Block after Surgery Involving the Foot and Ankle: Does it Improve the
Quality of Recovery? Anesthesia & Analgesia. 2003; 97: 1303-9.
13. Gottschalk A, et al. Continuous Wound Infi ltration with Ropivacaine Reduces Pain and Analgesic Requirement after
Shoulder Surgery. Anesthesia & Analgesia. 2003; 97: 1086-91.
14. Rawal N, et al. Patient-Controlled Regional Anesthesia (PCRA) at Home: Controlled Comparison between Bupivacaine and
Ropivacaine Brachial Plexus Analgesia. Anesthesiology. 96 (6): 1290-6.
15. Hoenecke H. Continuous Local Anesthetic Infi ltration. Orthopedic Technology Review. 2002; 3 (2): 1-4.
 
I-Flow currently has over 60 completed or on-going studies for ON-Q PainBuster and ON-Q C-bloc
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